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	<title>Concept Nutrition: Weight Management &#38; Health &#187; angiogenesis</title>
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	<link>http://conceptnutrition.com.au</link>
	<description>Live a healthy life you love - a Dietitian&#039;s Contribution</description>
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		<title>Anti-cancer foods</title>
		<link>http://conceptnutrition.com.au/anti-cancer-foods/</link>
		<comments>http://conceptnutrition.com.au/anti-cancer-foods/#comments</comments>
		<pubDate>Fri, 24 Oct 2008 04:40:27 +0000</pubDate>
		<dc:creator>Giselle</dc:creator>
				<category><![CDATA[Cancer]]></category>
		<category><![CDATA[angiogenesis]]></category>
		<category><![CDATA[anticancer diet]]></category>
		<category><![CDATA[inflammation]]></category>

		<guid isPermaLink="false">http://conceptnutrition.wordpress.com/?p=78</guid>
		<description><![CDATA[Let’s have a look at a list of common foods that make up the anti-cancer diet.]]></description>
			<content:encoded><![CDATA[<p>Thanks to major scientific breakthroughs in cancer research, the Achilles’ heel of cancer’s mechanism for promoting inflammation has been identified. This pro-inflammatory factor is Nuclear Factor-kappa B. According to Professor Albert Baldwin, most cancer prevention is aimed at inhibiting NF-kappa-B. As such, the whole pharmaceutical industry is looking for a drug to inhibit or block the inflammatory action of this key substance and prevent the spread of tumours. Another phenomenon that is important for tumour-growth/mortality is “angiogenesis”. In Greek, “angio” means vessels and “genesis” is birth. Blocking angiogenesis enables us to undercut cancer’s spread.<br />
Did you know that molecules known to act against NF-kappa B are freely available in common foods? Many of these molecules also block angiogenesis.</p>
<p>Let’s have a look at a list of common foods that make up the anti-cancer diet:<br />
<span id="more-15"></span></p>
<ol style="margin-top:0;" type="1">
<li><strong>green tea</strong> – contains polyphenols called “catechins” or epigallocatechin gallate (EGCG), EGCG blocks receptors on a cells surface that issue command for the creation of new blood vessels.</li>
<li><strong>red wine</strong> – “resveratrol” (this is <strong>not</strong> an endorsement to drink, quantities of &gt;100ml per day seem to lose their protective effect, Professor Riboli of the famous EPIC study thinks this study was poorly designed and conclusions dubious) </li>
<li><strong>garlic</strong> – “dialyl sulphide”</li>
<li><strong>cabbage, kale, brussels sprouts</strong> – cruciferous vegetables contain “indol-3-carbinol”</li>
<li><strong>rosemary</strong> – “carnosol”</li>
<li><strong>raspberries, strawberries, walnuts, hazel nuts</strong> and <strong>pecans</strong> – contain polyphenol called “ellagic acid”. Ellagic acid has been demonstrated to act against 2 most common mechanisms of stimulation of blood vessels: VEGF and PDGF.</li>
<li><strong>mushrooms</strong> – <a href="http://en.wikipedia.org/wiki/Shiitake">shiitake</a>, <a href="http://en.wikipedia.org/wiki/Maitake">maitake</a>, kawaratake, <a href="http://en.wikipedia.org/wiki/Enokitake">enokitake </a>contain “lentinan” and other polysaccharides</li>
<li><strong>broccoli</strong> – “sulphoraphane”</li>
<li><strong>turmeric</strong> – “curcumin”, a yellow powder used in Indian curries. Also, one of the most potent naturally occurring anti-inflammatory agents. In the laboratory it has been shown to inhibit angiogenesis and promote cancer cells death or cell “apoptosis”. Indians have less than 20% of colon, breast, lung and kidney cancers compared to Westerners of the same age.  This is true despite high exposure to environmental toxins on a worse scale than in the West.  Could their diet have something to do with the favourable statistics?</li>
<li><strong>tomatoes</strong> – “lycopene”</li>
<li><strong>soy beans</strong> – “genistein”, “daidzein” and “glyciteine”.  Researchers wrote that “soy and green tea may be used as potentially effective dietary regimen for inhibiting progression of oestrogen-dependent breast cancer”. Soy phyto-oestrogens act along similar lines as common breast cancer drug Tamoxifen.</li>
<li><strong>ginger</strong> – “6 -gingerol”</li>
<li><strong>cherries</strong> – “glucaric acid” which can facilitate elimination of xenoestrogens from environmental chemicals</li>
<li><strong>blueberries, cranberries, cinnamon, dark chocolate</strong> – “anthocyanidins” and “proanthocyanidins”</li>
<li><strong>parsley</strong> and <strong>celery</strong> – “apigenine”</li>
<li><strong>rosemary</strong>, <strong>thyme</strong>, <strong>oregano</strong>, <strong>basil</strong> and <strong>mint</strong> &#8211; essential oils of the terpene family</li>
<li><strong>seaweed</strong> &#8211; &#8220;fucoidan&#8221; and &#8220;fucoxanthin&#8221;</li>
<li><strong>salmon</strong>, <strong>tuna</strong>, <strong>trout</strong>, <strong>meckarel</strong>, <strong>cod</strong>, <strong>sardine</strong> &#8211; omega-3s</li>
<li><strong>orange</strong>, <strong>mandarin</strong>, <strong>lemon</strong>, <strong>grapefruit</strong> &#8211; anti-inflammatory &#8216;flavinoids&#8217;</li>
<li><strong>pomegranate</strong> &#8211; antioxidant</li>
<li><strong>yoghurt</strong> &#8211; &#8216;probiotics&#8217;</li>
<li><strong>vitamin D</strong></li>
<li><strong>selenium</strong></li>
</ol>
<p>In conclusion, we can make food our medicine and actively choose foods that defend our bodies against invasion of cancer by:</p>
<ol style="margin-top:0;" type="1">
<li>detoxifying carcinogens</li>
<li>boosting immune system and increasing natural killer (NK) cell production</li>
<li>blocking angiogenesis</li>
<li>blocking inflammation</li>
<li>promoting cancer cell “apoptosis” or cancer cell suicide</li>
</ol>
<p>References</p>
<ol>
<li>Y. Cao, R. Cao,&#8217;Angiogenesis inhibited by drinking tea&#8217; <em>Nature</em>, 398 (6726), 1999; 381.</li>
<li>I. J. Fidler, &#8216;Angiogenic heterogeneity:regulation of neoplastic angiogenesis by the organ microenvironment&#8217; <em>Journal of the National Cancer Institute</em>, 93(14), 2001; 1040-41.</li>
<li>S. Paget, &#8216;The distribution of secondary growths in cancer of the breast&#8217; <em>Lancet</em> 1889; 1:571-3.</li>
<li>Y. J. Surh, &#8216;Cancer chemoprevention with dietary phytochemicals&#8217; <em>Nature Reviews Cancer</em>, 3(10), 2003: 768-80.</li>
<li>J. Jankun, S. H. Selman, R. Swierz, E. Skrzypczak-Jankun, &#8216;Why drinking green tea could prevent cancer&#8217; <em>Nature</em>, 387(6633), 1997: 561.</li>
<li>M. Demeule, B. Annabi, J. Michaud-Levesque, S. Lamy, R. Beliveau, &#8216;Dietary prevention of cancer: Anticancer and antiangiogenic properties of green tea polyphenols&#8217; <em>Medicinal Chemistry Reviews</em> &#8211; Online 2, 2005: 49-58.</li>
<li>J. R. Zhou, L. Yu, Z. Mai, G. L. Blackburn, &#8216;Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice&#8217; <em>International Journal of Cancer</em>, 108(1), 2004; 8-14.</li>
<li>J. R. Zhou, L. Yu, Y. Zhong, G. L. Blackburn, &#8217;Soy phytochemicals and tea bioactive components in mice&#8217; <em>Journal of Nutrition</em>, 133(2), 2003: 516-21.</li>
<li>A. H. Wu, M. C. Pike, D, O. Stram, &#8216;Meta-analysis: Dietary fat intake, Serum Estrogen levels and the Risk of Breast Cancer&#8217; <em> Journal of the National Cancer Institute</em>, 1999: 529-34.</li>
<li>K. Mehta, P. Pantazis, T. McQueen, B.B. Aggarwal, &#8216;Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumour cell lines&#8217; <em>Anticancer Drugs</em>, 8(5), 1977: 470-81.</li>
<li>S. Shishodia, B.B. Aggarwal, &#8216;Nuclear factor-kappa B activation: a question of life or death&#8217; <em>Journal of Biochemistry and Molecular Biology</em>, 35(1), 2002: 28-40.</li>
<li>B. B. Aggarwal, S. Shishodia, Y. Takada, et al. &#8216;Curcumin suppresses the paclitaxel-induced nuclear factor kappa B pathway in breast cancer cells and inhibits lung metestasis of human breast cancer in nude mice&#8217; <em>Clinical Cancer Research</em>, 11(20), 2005: 7490-98.</li>
<li>P. M. Kidd, &#8216;The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment&#8217; <em>Alternative Medicine Review</em>, 5(1), 2000: 4-27.</li>
<li>H. Nakazato, A. Koike, S. Saji, N. Ogawa, J. Sakamoto, &#8216;Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer&#8217; <em>Lancet</em>, 343, 1994: 1122-6.</li>
<li>M. Hara, T. Hanaoka, M. kobayashi, et al. &#8216;Cruciferous vegetables, mushrooms and gastrointestinal cancer risks in a multicentre, hospital-based case-control study in Japan&#8217; <em>Nutrition Cancer</em>, 46(2), 2003: 138-47.</li>
<li>L. Labrecque, S. Lamy, A. Chapus, et al. &#8216;Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound&#8217; <em>Carcinogenesis</em>, 26(4), 2005: 821-6.</li>
<li>N. Seeram, L. Adams, Y. Zhang, et al. &#8216;Blackberry, black raspberry, blueberry, cranberry, red raspberry and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro&#8217; <em>Journal of Agricultural Food Chemicals</em>, 54, 2006L 9329-39.</li>
<li>R. Smith &#8216;Let food be thy medicine&#8230;&#8217; <em>British Medical Journal</em>, 2004: 328.</li>
<li>H. Kikuzaki, N. Nakatani, &#8216;Antioxidant effects of some ginger constituents&#8217; <em>Journal of Food Science</em>. 58(6), 1993, 1407-10.</li>
<li>C. M. Cover, S. J. Hsieh, E. J.Cram. et al. &#8216;Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF &#8211; 7 human breast cancer cells&#8217; <em>Cancer Research</em>, 59(6), 1999: 1244-51.</li>
<li>L. Gamet-Payraste, P. Li, S. Lumeau, et al. &#8216;Sulforaphane, a Naturally Occuring Isothiocyanate, Induces cell Cycle Arrest and Apoptosis in HT29 Human Colon Cancer Cells&#8217; <em>Cancer Research</em>, 60(5), 2000: 1426-33.</li>
<li>P. Terry, A. Wolk, H. Vainio, E. Weiderpass, &#8216;Fatty fish consumption lowers the risk of endometrial cancerL a nationwide case-control study in Sweden&#8217; <em>Cancer Epidemiology, Biomarkers &amp; Prevention</em>, 11(1),  2002; 143-5.</li>
<li>P. Terry, P. Lichtenstein, M. Feychting, A. Ahlbom, A. Wolk, &#8216;Fatty fish consumption and the risk of prostate cancer&#8217; <em>Lancet</em>, 357(9270), 2001: 1765-6.</li>
<li>C. H. MacLean, S. J. Newberry, W. A. Mojica, et al. &#8216;Effects of omega-3 fatty acids on cancer risk: a systematic review&#8217; <em>JAMA</em>, 295(4), 2006: 403-15.</li>
<li>M. P. Rayman, &#8216;The importance of selenium to human health&#8217; <em>Lancet</em>, 356(9225), 2000: 233-41.</li>
<li>J. M. Lappe, K. Travers-Gustafson, K. M. Davies, R. R. Recker, R. P. Heaney, &#8216;Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial&#8217; <em>American Journal of Clinical Nutrition</em>, 85, 2007: 1586-91.</li>
<li>R. Beliveau, D. Gingras, &#8216;Green tea: prevention and treatment of cancer by nutraceuticals&#8217; <em>Lancet</em>, 354(9439), 2004:1021-2.</li>
<li>D. P. Rose, J. M. Connolly, &#8216;Regulation of tumour angiogenesis by dietary fatty acids and eicosanoids&#8217; <em>Nutr Cancer</em>, 37(2), 2000:119-27.</li>
<li>T. Norat, S. Bingham, P. Ferrari, et al. &#8216;Meat, fish and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition&#8217; <em>Journal of National Cancer Institute</em>, 97(12), 2005:906-16.</li>
<li>P. Terry, P. Lishtenstein, M. Feychting, A. Ahlbom, A. Wolk, &#8216;Fatty fish consumption and risk of prostate cancer&#8217; <em>Lancet</em>, 357(9270), 2001: 1764-6.</li>
<li>L. T. Hooper, R. Thompson, R. Harrison, et al. &#8216;Risks and benefits of omega-3 fatty acidson cancer risk: a systematic review&#8217; <em>JAMA</em>, 295(4), 2006: 403-15.</li>
<li>M. P. Rayman, &#8216;The importance of selenium to human health&#8217; <em>Lancet</em>, 356(9225), 2000:233-41.</li>
<li>L. Kiremidjian-schumacher, M. Roy, H. I. Wishe, M. W. Cohen, G. Stotzky &#8216;Supplementation with selenium and human immune cell functios. II. Effect on cytotoxic lymphocytes and natural killer cells&#8217; <em>Biological Trace Element Research</em>, 41(1-2), 1994: 115-27. </li>
<li>J. M. Lappe, k. Travers-Gustafson, K. M. davies, R. R. Recker, R. P. Heaney, &#8216;Vitamin D and calcium supplementation reduces cancer risk: results of a randomised trial&#8217; <em>American Journal Clinical Nutrition</em>, 85, 2007: 1586-91.</li>
</ol>
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